Role of NADPH Oxidase in Microvascular Dysfunction Following GDM

ConditionsGestational Diabetes Oxidative Stress Vascular Endothelial Function

Trial statusRecruiting

Trial phaseEarly Phase 1

Trial typeInterventional

Biological sexFemale

Age18-50

SponsorAnna Stanhewicz, PhD

About this trial

The purpose of this investigation is to examine NADPH oxidase as a source of reactive oxygen species contributing to aberrant microvascular function in otherwise healthy women with a history of GDM.

Eligibility criteria

Qualifiers

18 years or older

pregnant within 5 years of the study visit

had gestational diabetes diagnosed by their obstetrician and confirmed according to the American College of Obstetricians and Gynecologists criteria for gestational diabetes.

or without a history of gestational diabetes

Disqualifiers

skin diseases

current tobacco or electronic cigarette/vape pen use,

diagnosed or suspected hepatic or metabolic disease including diabetes,

statin or other cholesterol-lowering medication,

Trial design

Treatments tested in this trial

Acetylcholine
Insulin aspart

Treatment groups

40 Participants

are divided into 4 treatment groups

Sponsors and collaborators

Anna Stanhewicz, PhD

Lead sponsor

University of Iowa

Sponsor institution

Source ClinicalTrials.gov