Safety and Efficacy of Metabolically Armed Tumor-lnfiltrating Lymphocytes (Meta10-TIL) for the Treatment of Advanced Solid Tumors

Trial statusRecruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age19-70
SponsorAnhui Provincial Hospital

About this trial

A Study of Metabolically Armed Tumor-Infiltrating Lymphocytes (Meta10-TIL) Therapy for Patients With Advanced Solid Tumors

Eligibility criteria

Qualifiers

The patient or his/her guardian voluntarily signed the informed consent;

Age >18 years and ≤70 years, male or female;

Recurrent/metastatic/persistent cervical cancer with prior failure (disease progression or intolerable toxicity) of at least 1 but no more than 3 systemic therapies;

Systemic therapy is defined as any chemotherapy or multi-drug combination chemotherapy regimen recommended by guidelines used for cervical cancer;

Disqualifiers

Presence of bone metastases only.

Active central nervous system (CNS) metastases (except for stable brain metastases not requiring medication or steroid dependence for ≥3 months).

Use of Chinese herbal medicine or botanical drugs with antitumor indications within 1 week before preconditioning.

Systemic corticosteroid therapy (≥10 mg/day prednisone or equivalent) or other immunosuppressive drugs within 2 weeks before preconditioning (excluding inhaled, topical, or physiological replacement therapy).

Trial design

Treatments tested in this trial

  • Metabolically Armed TIL cells

Treatment groups

36 Participants
are divided into 1 treatment group

Sponsors and collaborators

Anhui Provincial Hospital

Lead sponsor

Leman Biotech Co., Ltd.

Collaborator