Single-tracer Multiparametric PET Imaging
Trial statusRecruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of California, Davis
About this trial
The overarching goal of this project is to develop and evaluate a single-tracer multiparametric positron emission tomography (PET) imaging solution for simultaneous imaging of blood flow and glucose metabolism using 18F-fluorodeoxyglucose (FDG) alone. The investigators working hypothesis is that quantitative blood flow can be extracted from dynamic 18F-FDG PET data by use of tracer kinetic modeling, in addition to glucose metabolism that 18F-FDG is conventionally used for.
Eligibility criteria
Qualifiers
Adults (age ≥ 18 years old)
Ability to understand and willingness to sign an informed consent form
Ability to adhere to the study visit schedule and other protocol requirements.
Willing and able to fast for at least 6 hours before and for the duration of the scan
Disqualifiers
Self-reported history of dysphoria or anxiety in closed spaces
Body weight >240 kg due to limitations of the scanner bed
Pregnant or breast-feeding (due to risks of ionizing radiation; urine pregnancy test will be administered prior to start of each PET/CT session for all participants between 18 to 60 years old who are able to get pregnant, unless documented hysterectomy or bilateral ovarian removal is available)
Blood glucose greater than 200 as assessed by fingerstick method before injection of 18F-FDG
Trial design
Treatments tested in this trial
- 18F-FDG
- 11C-butanol
Treatment groups
60 Participants
are divided into 1 treatment groupSponsors and collaborators
University of California, Davis
Lead sponsor
National Institute for Biomedical Imaging and Bioengineering (NIBIB)
Collaborator
Source ClinicalTrials.gov