A clinical trial comparing preemptive multimodal analgesics with placebo in the management of immediate and chronic post-endodontic pain. The study utilizes statistical methods such as chi-squared, T-tests, and regression analysis, accounting for multiple outcomes with the Bonferroni adjustment. Duloxetine hydrochloride and pregabalin, both available in Bangladesh, are evaluated as experimental drugs, while placebos are used to assess psychological effects on pain. All participants receive standard interventional treatments, with acetaminophen provided as needed, and ethical considerations are addressed according to international guidelines.
Patient's aged 18 years more.
ASA physical status I-II.
Patient with the complain of pain originated from teeth and surrounding structure.
Preoperative pain severity is moderate to severe.
Patient would not like to attain in research.
Patients have any medical condition those are contra indication for study drug.
ASA physical status III, IV, V.
Patient already under treated any anti convulsent drug.