The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response
Trial statusRecruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age18-45
SponsorBeth Israel Deaconess Medical Center
About this trial
The goal of this clinical trial is to learn about the processes occurring in the kidneys while under heat stress in healthy volunteers. The main questions it aims to answer are:
* How do the chemicals produced by the body change under conditions of higher versus lower heat stress? * What role does a specific area of the body's metabolism, known as NAD+ metabolism, play in the body's response to heat stress, and can this response be modified by taking vitamin B3?
Eligibility criteria
Qualifiers
Healthy volunteer
Any race
Estimated glomerular filtration rate greater than 90 ml/min/1.73m2
Urine albumin/creatinine ratio less than 30mg/g
Disqualifiers
Medical condition preventing safe participation in exercise during heat
Allergy to Vitamin B3
Severe food allergies or dietary restrictions that would preclude eating the planned study diet without major modifications
Trial design
Treatments tested in this trial
- Vitamin B3
Treatment groups
28 Participants
are divided into 2 treatment groupsSponsors and collaborators
Beth Israel Deaconess Medical Center
Lead sponsor
Boston University Charles River Campus
Collaborator
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator
Source ClinicalTrials.gov