The Role of the Opioid System in Placebo Effects on Pain and Social Rejection
Trial statusNot yet recruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age18-55
SponsorTrustees of Dartmouth College
About this trial
The current study probes the involvement of the opioid system in placebo effects on social pain, using the opioid antagonist naloxone. 60 participants who recently experienced an unwanted breakup will experience rejection-related stimuli and receive painful heat and pressure stimuli during fMRI scanning. Participants will be randomized to receive either a naloxone or saline nasal spray, and be informed that the spray is either saline, or an effective pain and negative emotion reducing agent.
Eligibility criteria
Qualifiers
Adults aged 18-55 years
No current psychiatric or major neurological diagnosis
No reported substance abuse within the last six months
Are capable of performing experimental tasks (e.g., are able to read, able to cooperate with fMRI examination)
Disqualifiers
Current presence of pain
Current or past history of primary psychiatric disorder
Current or past history of psychoactive substance abuse or dependence
Dementias
Trial design
Treatments tested in this trial
- Placebo Cream with Naloxone
- Control Cream with Naloxone
- Placebo Cream with Saline
- Control Cream with Saline
Treatment groups
60 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov