Type 2 Diabetes and Blood Brain Barrier Improvement
ConditionType2diabetes
Trial statusRecruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age40-65
SponsorUniversity of California, Los Angeles
About this trial
The majority of T2DM adults show thiamine (vitamin B1) deficiency which may contribute to impaired function. This study will examine patients with T2DM through brain MRI scans, cognition assessments, blood tests, and questionnaires. Our goal is to see if a thiamine treatment (taking vitamin B1 capsules) can improve function. Patients will be asked to come to UCLA two times three months apart and each visit will last about 2.5-3 hours.
Eligibility criteria
Qualifiers
Diagnosed T2DM
Outpatient status
Able to lay flat for imaging
Disqualifiers
A previous history of stroke
Current in-take of thiamine
Known thiamine allergy
Seizure disorder
Trial design
Treatments tested in this trial
- Thiamine
- Placebo
Treatment groups
52 Participants
are divided into 2 treatment groupsSponsors and collaborators
University of California, Los Angeles
Lead sponsor
National Institute on Aging (NIA)
Collaborator
Source ClinicalTrials.gov