About this trial
The researchers will examine functional neural correlates that differentiate between laryngeal dystonia and voice tremor and contribute to disorder-specific pathophysiology using a cross-disciplinary approach of multimodal brain imaging.
Eligibility criteria
Qualifiers
Males and females of diverse racial and ethnic background;
Age 18-80 years;
Native English speakers;
Right-handed;
Disqualifiers
Subjects who are incapable of giving informed consent;
Pregnant or breastfeeding women until a time when they are no longer pregnant or breastfeeding. All women of childbearing potential will have a urine pregnancy test performed before MRI, which must be negative for participation in the imaging studies;
Subjects with a past or present medical history of (a) neurological problems, such as stroke, movement disorders (other than specified LD and VT in the patient groups), brain tumors, traumatic brain injury with loss of consciousness, ataxias, myopathies, myasthenia gravis, demyelinating diseases; (b) psychiatric problems, such as schizophrenia, bipolar depression, obsessive-compulsive disorder, alcoholism, drug dependence; (c) laryngeal problems, such as vocal fold paralysis, paresis, vocal fold nodules and polyps, carcinoma, chronic laryngitis;
Patients with any other form of dystonia;
Trial design
Treatments tested in this trial
- Brain imaging
- Laryngeal sensory block with topical bupivacaine
Treatment groups
Sponsors and collaborators
Massachusetts Eye and Ear Infirmary
Lead sponsor
University of California, San Francisco
Collaborator