Vitamin C and Hiprex in rUTI
ConditionUrinary Tract Infections
Trial statusNot yet recruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexFemale
Age18+
SponsorUniversity Hospitals of North Midlands NHS Trust
About this trial
A single centre proof of concept study to assess whether Vitamin C improves the efficacy of Methenamine Hippurate (Hiprex®) in the prophylaxis of recurrent urinary tract infections (rUTIs) in women
Eligibility criteria
Qualifiers
Female
Age ≥18 years
Recurrent proven UTI, defined as "two or more proven infections in six months or three or more infections in six months"
Willing and able to give fully informed consent
Disqualifiers
Males
Women who are pregnant or breast-feeding
Contraindications to methenamine hippurate as described in BNF: known allergy, gout, severe metabolic acidosis, severe dehydration, eGFR less than 10 ml/min, severe hepatic impairment
Currently using vitamin C containing supplement or cranberry extract tablets
Trial design
Treatments tested in this trial
- Methenamine Hippurate 1g BD
- Methenamine Hippurate 1g BD + Vitamin C 1g BD
Treatment groups
20 Participants
are divided into 3 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov