Early Pulmonary Dysfunction in Childhood Cancer Patients
ConditionPulmonary Dysfunction
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age4-22
SponsorUniversity Children's Hospital Basel
About this trial
This longitudinal, prospective, multicentre study is to monitor lung function prospectively in childhood cancer patients after diagnosis. The impact of cancer treatment on pulmonary dysfunction non-invasively using lung function, lung imaging and breath analysis as well as clinical symptoms using a questionnaire will be assessed at different time points.
Eligibility criteria
Qualifiers
chest radiation
treatment with any kind of chemotherapy
hematopoietic stem cell transplantation (HSCT)
thoracic surgery
Disqualifiers
no signed informed consent
Operation outside the chest area as only cancer treatment
Relapsed cancer (patients who develop relapse during the study will not be excluded)
Subjects who are respiratory insufficient and cannot perform a lung function test (less than 92% O2 saturation; under O2 therapy)
Trial design
Treatments tested in this trial
- Lung function measurements
- Breath Analysis
- Magnetic resonance imaging (MRI)
- Standardized interview to assess respiratory symptoms
- Data collection for assessment of clinical parameters and cumulative doses to chemotherapy, radiation, surgery and HSCT
- Collection of genetic samples
Treatment groups
No treatment groups listed
Sponsors and collaborators
Source ClinicalTrials.gov