Early Switch from Controlled to Assisted Ventilation
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorErasmus Medical Center
About this trial
The goal of this physiological intervention study is to unravel the (patho)physiological mechanisms and potential clinical benefits of a pre-specified early switch from controlled to assisted ventilation in mechanically ventilated adult patients with acute hypoxemic respiratory failure (PaO2/FiO2 ratio \< 200 mmHg).
The intervention is that participants will be switched from controlled to assisted ventilation when PaO2/FiO2 ratio \> 200 mmHg.
The primary endpoint is the change in regional lung stress (as derived by electrical impedance tomography) when switching from controlled to assisted ventilation and until a successful or failed switch.
Eligibility criteria
Qualifiers
18 years old
Written informed consent from a legal representative
Mechanical ventilation via an endotracheal tube
Acute hypoxemic respiratory failure with PaO2/FiO2 ratio < 200 mmHg
Disqualifiers
Expected mechanical ventilation duration of <48 hours
Pure chronic obstructive pulmonary disease exacerbation
Pre-existent respiratory muscle disease
Contraindication to EIT monitoring (as per clinical protocol, e.g. pacemaker, burns or thoracic wounds limiting electrode placement)
Trial design
Treatments tested in this trial
- Pre-specified switch from controlled to assisted ventilation when PaO2/FiO2-ratio > 200 mmHg
Treatment groups
20 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov