Early Transjugular Intrahepatic Portosystemic Shunt for Advanced Hepatocellular Carcinoma
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-75
SponsorSun Yat-sen University
About this trial
Hepatocellular carcinoma (HCC) with main trunk portal vein tumor thrombus (PVTT) has poor prognosis. The main lethiferous factor is the upper gastrointestinal hemorrhage by PVTT-related portal hypertension. Studies have proven that early transjugular intrahepatic portosystemic shunt (TIPS) with 72 hours after acute variceal bleeding is effective.
Eligibility criteria
Qualifiers
diagnosis of primary HCC, confirmed histologically or clinically according to the criteria of the American Association for the Study of Liver Diseases;
presence of PVTT with III-IV grade by Cheng's criteria;
having PVTT induced portal hypertension;
TIPS was performed within 72 hours after the endoscopic hemostasis;
Disqualifiers
recurrent HCC;
PVTT at I-II grade by Cheng's criteria;
age < 18 years or > 75 years;
advanced HCC with more than five metastases;
Trial design
Treatments tested in this trial
- Early TIPS
Treatment groups
22 Participants
are divided into 1 treatment groupSponsors and collaborators
Sun Yat-sen University
Lead sponsor
Chinese PLA General Hospital
Collaborator
Source ClinicalTrials.gov