Early Use of Airway Pressure Release Ventilation (APRV) in ARDS
ConditionAcute Respiratory Distress Syndrome
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorHospital Civil de Guadalajara
About this trial
Airway pressure release ventilation (APRV) is a time-cycled, pressure controlled, intermittent mandatory ventilation mode with extreme inverse I:E ratios. Currently it is considered as a non-conventional ventilatory mode. The investigators aim to compare APRV with conventional mechanical ventilation (MV) in patients with acute respiratory distress syndrome (ARDS).
Eligibility criteria
Qualifiers
Acute respiratory distress syndrome, according to the Berlin definition of ARDS, with adjusted pO2/FiO2 for altitude <300, and less than 48 h of endotracheal mechanical ventilation
Disqualifiers
Pregnancy
Less than 18 years-old
Expected duration of mechanical ventilation less than 48 h
Preexisting conditions with an expected 3-month mortality exceeding 50%
Trial design
Treatments tested in this trial
- APRV. General Electric Healthcare Engstrom ventilator system
- Conventional. General Electric Healthcare Engstrom ventilator system
Treatment groups
150 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov