Health Trials

Early WAKE-up Predictors After Out-of-Hospital Cardiac Arrest

ConditionsCardiac Arrest (CA)Anoxic Brain InjuryComatose Survivors of Cardiac ArrestEEGPupillometryOptic Nerve Sheath DiameterTranscranial Doppler UltrasoundNeurological Outcome
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity of Aarhus

About this trial

WAKE-OHCA is a prospective observational substudy of the Danish Out-of-Hospital Cardiac Arrest (DANOHCA) trial, identifier NCT05895838. The aim is to collect early neuromonitoring data to identify key predictors of successful wake-up.

Eligibility criteria

Qualifiers

Age ≥18 years

OHCA of presumed cardiac cause

Sustained ROSC, defined as persistent signs of circulation and no need for chest compressions or mechanical circulatory support for 20 minutes

Unconsciousness (GCS <9) (patients not able to obey verbal commands) after sustained ROSC at the time of randomization

Disqualifiers

Females of childbearing potential if pregnancy is suspected (unless a negative HCG test can rule out pregnancy within the inclusion window)

Known bleeding diathesis (medically induced coagulopathy (e.g. warfarin, NOAC, clopidogrel) does not exclude the patient)

Suspected or confirmed acute intracranial bleeding

Suspected or confirmed acute stroke

Trial design

Treatments tested in this trial

  • Automated Pupillometry
  • Transcranial Doppler Ultrasound
  • Optic Nerve Sheath Diameter
  • Continuous EEG and EEG Reactivity

Treatment groups

No treatment groups listed

Sponsors and collaborators

University of Aarhus

Lead sponsor

Aarhus University Hospital

Collaborator

Rigshospitalet, Denmark

Collaborator

Source ClinicalTrials.gov