Eccentric Cycling in Multiple Sclerosis Rehabilitation
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-75
SponsorUniversity of Liege
About this trial
The project aims to optimise functional rehabilitation programmes for people with multiple sclerosis.
Investigators are proposing eccentric cycling as a new exercise modality for treating these patients.
Based on previous results in healthy subjects, investigators will attempt to define the optimal parameters of this new modality (in terms of duration, intensity, frequency, etc.).
Investigators also aim to demonstrate the effectiveness of this training (compared to conventional training) in improving muscle function, functional capacity, perception of chronic fatigue, quality of life, physical condition, and neurological and cognitive function.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Diagnosis of multiple sclerosis
Multiple sclerosis: EDSS score < 7
Age under 75 years
Stable disease state
Disqualifiers
One or more contraindications to physical activity
Significant comorbidities
Current hospitalization or undergoing changes in medication
Active flare-up
Trial design
Design model
Parallel
Treatments tested in this trial
Eccentric training
Other interventionEccentric cycling training
Concentric training
Other interventionConcentric cycling training
Treatment groups
60 Participants
are divided into 2 treatment groupsGroup A: Eccentric groupExperimental treatment 1 intervention
Group B: Concentric groupActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Maximal Isometric Force
Maximal Isometric Force (in Newton-meters - Nm) of the quadriceps will be measured using a fixed dynamometer (Kinvent), at 90 degrees of knee flexion.
Time frame
At baseline and endline of intervention (Week 1 and 14)2
Walking distance
6 minutes walking test and 2 minutes walking test will be performed to measure the walking capacities (in meters) of participants.
Time frame
At baseline and endline of intervention (Week 1 and 14)Secondary outcomes
1
Handgrip strength
Handgrip strength (in kilograms) will be measured using a handheld dynamometer.
Time frame
At baseline and endline of intervention (Week 1 and 14)2
Spasticity
Spasticity will be evaluated using the Tardieu's scale of spasticity (expressed in arbitrary unit). This scale ranges from 0 (no resistance) to 4 (immobile)
Time frame
At baseline and endline of intervention (Week 1 and 14)3
Timed up and go
The TUAG (in seconds) will be used to evaluate lower limb functional capacity
Time frame
At baseline and endline of intervention (Week 1 and 14)4
Neurocognitive capacity
Neurocognitive capacity will be evaluated using a combinaison of Tests of Attentional Performance battery (TAP battery)
Time frame
At baseline and endline of intervention (Week 1 and 14)Other outcomes
1
Height
Height will me measured and expressed in centimeters.
Time frame
At baseline and endline of intervention (Week 1 and 14)2
Weight
Weight in kilograms will be measured using a Tanita scale.
Time frame
At baseline and endline of intervention (Week 1 and 14)3
Body fat percentage
Body fat percentage (in percent) will be measured using a Tanita scale.
Time frame
At baseline and endline of intervention (Week 1 and 14)4
Body mass index
BMI (in kilograms per square meters) will be measured using the height and the weight (H/W\^2).
Time frame
At baseline and endline of intervention (Week 1 and 14)Sponsors and contacts
Click on the lead sponsor to view all of their trials.
University of Liege
Lead sponsor
University Hospital Sart Tilman, Liege
Collaborator
Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: