About this trial
This study aims to assess whether electroencephalogram (EEG) and nociception level-guided anesthesia can improve quality of recovery after laparoscopic gynecological surgery compared with standard care. Patients will be randomly assigned to either EEG and Analgesia Nociception Index (ANI)-guided anesthesia group (EEG-and-ANI-Guided group) or usual care group (control group). Primary outcome is 15-item Quality of Recovery (QoR-15) score at postoperative day (POD) 1. Secondary outcomes included remifentanil consumption during anesthesia, occurrence of awareness with recall, incidence of undesirable intraoperative movement, emergence time, postoperative pain scores, quality of recovery score at POD 2, and length of hospital stay.
Eligibility criteria
Qualifiers
Total laparoscopic hysterectomy with/without salpingo-oophorectomy
Laparoscopic myomectomy
Laparoscope-guided salpingo-oophorectomy
Laparoscope-guided ovarian cystectomy
Disqualifiers
Patients with nonregular sinus cardiac rhythm
Patients with implanted pacemakers
Patients on antimuscarinic agents, α2-adrenergic agonists, β1-adrenergic antagonists, antiarrhythmic agents
pregnant or breastfeeding women
Trial design
Treatments tested in this trial
- EEG-and-ANI-guided anesthesia
- standard anesthesia
- Sevoflurane and remifentanil
- EEG and ANI