This randomized crossover study investigates the effect of consuming a high-protein, high-fiber pre-fast meal on subjective satiety and glycemic responses during fasting hours in healthy adults. Participants will complete two dietary conditions in a randomized order: a standardized high-protein, high-fiber pre-fast meal and a low-protein, low-fiber pre-fast meal guided by dietary instructions. Each condition will be followed for two consecutive days and separated by a three-day washout period. Outcomes include subjective appetite sensations during fasting hours, glycemic profiles assessed using continuous glucose monitoring (CGM), and exploratory analyses examining the association between glucose dynamics and appetite sensations.
Adults aged 18 years and older
Willingness to comply with study procedures, including fasting and continuous glucose monitoring
Ability to provide informed consent
Diagnosed diabetes mellitus or known metabolic disease
History of cardiovascular, gastrointestinal, or endocrine disorders that may affect study outcomes
Use of medications known to affect glucose metabolism or appetite
Pregnancy or lactation
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Saudi ArabiaKing Faisal University
Lead sponsor
Saudi Food and Drug Authority
Collaborator