The goal of this clinical trial is to evaluate the effect of catheter ablation of persistent atrial fibrillation on cognitive function in patients with mild cognitive impairment. Participants will be randomized into antiarrhythmic drugs alone or atrial fibrillation ablation + antiarrhythmic drugs.
Patients aged 60 to 80 years
Persistent atrial fibrillation
Patients with an indication for cardiac rhythm control.
Montreal Cognitive Assessment score between 18 and 25 points corresponding to mild cognitive impairment
Impossibility to perform the neuropsychological evaluation (communication problems such as hearing loss or aphasia, language barrier)
History of clinical stroke
Presence of a bruit at carotid auscultation or history of severe carotid stenosis
History or suspicion of neurodegenerative disease (Parkinson's disease, Alzheimer's disease, Huntington's disease and amyotrophic lateral sclerosis...), bipolar disorder, schizophrenia, severe depression or amyloidosis