Effect of Accelerated Neuromodulation of Anterior Cingulate Cortex to Enhance Cognition in Older Adults With Mild Memory Problems

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age55-85
SponsorRotman Research Institute at Baycrest

About this trial

The goal of this clinical trial is to test whether an accelerated deep Transcranial Magnetic Stimulation (dTMS) protocol in combination with cognitive training can improve cognitive abilities in older adults with Subjective Cognitive Decline (SCD) or Mild Cognitive Impairment (MCI). The study will look at whether it is safe and tolerable to use accelerated dTMS to enhance the benefits of cognitive training in older adults, and will also gather early information on the effects of accelerated dTMS on memory and other cognitive abilities.

Eligibility criteria

Qualifiers

55 - 85 years of age (on the day of randomization)

are male or post-menopausal female

have a diagnosis of mild cognitive impairment (MCI) based on Montreal Cognitive Assessment score < 26 or where available, results from clinical neuropsychological assessment, OR subjective memory concerns and first degree relative, living or deceased, with a probable or confirmed diagnosis of AD

score 24 or higher on the Mini Mental State Examination (MMSE)

Disqualifiers

have a metal plate in their head(such as an ear implant, implanted brain stimulators, aneurysm clips). Dental devices and implants that are non-magnetic are safe.

have known increased pressure or a history of increased pressure in their brain, which may increase their risk for having seizures

have a cardiac pacemaker

have an implanted medication pump

Trial design

Treatments tested in this trial

  • Active Brainsway H7-Coil Deep TMS System
  • Sham Brainsway H1-Coil Deep TMS System

Treatment groups

30 Participants
are divided into 2 treatment groups