There is no specific therapy for acute kidney injury. It is presumed that supportive measures improve the care and outcome of patients with acute kidney injury.
To investigate whether an implementation of a supportive extended care "bundle" in high-risk patients for persistent acute kidney injury (AKI) can reduce the occurrence of persistent surgical AKI.
In order to investigate whether the extended KDIGO bundle can prevent persistent AKI in patients with high chemokine ligand 14 (CCL14) as well as in patients with low CCL14, patients will be randomized with stratification by the CCL-value.
Adult patients (age ≥18 years)
Moderate or severe AKI ((defined by the 2012 KDIGO criteria, KDIGO stage 2 and 3), determined by either serum creatinine or urine output) within 72h after a surgical procedure
Written informed consent
Dialysis-dependent chronic kidney disease
Prior kidney transplant
Infections with human immunodeficiency virus or hepatitis
Hepatorenal syndrome
University Hospital Muenster
Lead sponsor
Baxter Healthcare Corporation
Collaborator