Effect of Antibiotic Pretreatment on the Efficacy of WMT in the Treatment of Chronic Constipation

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorFaming Zhang

About this trial

This is a randomized controlled trial to explore the efficacy of antibiotic pretreatment on the efficacy of WMT in the treatment of chronic constipation in adults: a multi-center, randomized, placebo-controlled clinical study

Eligibility criteria

Qualifiers

Male and female, aged ≥18 years old, provided written informed consent;

Disqualifiers

Presence of outlet obstruction and constipation, such as rectal mucosal prolapse

Combined with the results of colonoscopy in the past 24 months, those with intestinal stenosis caused by organic lesions of the digestive tract (such as tumor, inflammation, anal fissure, Crohn's disease, ulcerative colitis, intestinal adhesion, intestinal tuberculosis, etc.) and constipation;

Constipation caused by other systemic diseases involving the digestive tract, such as nervous system diseases (such as Parkinson's disease, spinal cord injury, multiple sclerosis, etc.), muscle diseases (such as amyloidosis, dermatomyositis, etc.), mental disorders (such as depression, etc.), metabolic and endocrine disorders (such as diabetes, hypothyroidism, etc.) or opioids, etc.

Has a history of abdominal pelvic surgery, but after cystic resection, cesarean section, does not appear after appendectomy postoperative intestinal complications, and intestinal polyps except after treatment;

Trial design

Treatments tested in this trial

  • Ornidazole
  • Placebo

Treatment groups

96 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Faming Zhang

Lead sponsor

The Second Hospital of Nanjing Medical University

Sponsor institution