About this trial
This study investigates the effect of apneic oxygenation of the non-ventilated lung on local and systemic inflammatory response during lung cancer surgery.
Patients undergoing surgical resection of lung cancer often require one-lung ventilation during anaesthesia. This results in alveolar hypoxia accompanied by upregulated expression of inflammatory markers. Apneic oxygenation of the non-ventiladed lung may influence inflammatory processes and oxygenation during surgery. The aim of this study is to evaluate whether apneic oxygenation affects inflammatory markers in lung tissue and postoperative recovery in patients undergoing lung cancer surgery. The study is conducted at a single center and includes adult patients scheduled for elective lung cancer surgery. Data will be collected durig the perioperative period. The results of this study may contribute to improved anaesthetic management and patient outcomes during thoracic surgery.
Eligibility criteria
Qualifiers
Adults aged 18 years or older
Patients scheduled to undergo surgical resection of a single lung segment for lung cancer
Written informed consent provided
Disqualifiers
Age younger than 18 years
Chronic corticosteroid therapy and/or other immunomodulatory treatments
Surgical procedure expected to last less than 2 hours
Intraoperative hemodynamic instability, defined as: Mean arterial pressure < 60 mmHg for more than 30 minutes despite adequate volume resuscitation, requirement for high-dose vasopressor support (norepinephrine > 0.2 µg/kg/min)
Trial design
Treatments tested in this trial
- Apnoeic Oxygenation
- Standard Ventilation