Effect of Breathing Training on Symptoms of Gastroesophageal Reflux Disease

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age20-80
SponsorChanghua Christian Hospital

About this trial

The goal of this clinical trial is to evaluate whether two types of breathing training can improve symptoms of gastroesophageal reflux disease (GERD) in adults.

The main research questions are:

* Do volume-oriented incentive spirometry (VIS) or diaphragmatic breathing exercise (DBE) improve GERD symptoms compared with usual care? * Do these breathing exercises reduce the symptoms of GERD? * Does volume-oriented incentive spirometry (VIS) produce greater improvement in GERD symptoms compared with DBE? * Do these exercises increase the strength of the lower esophageal sphincter (LES)?

Researchers will compare VIS training, DBE training, and usual care to determine whether breathing training can serve as a safe and effective non-pharmacological treatment option for GERD.

Participants will:

* Be randomly assigned to VIS training, DBE training, or usual care * Perform their assigned breathing training (if in the intervention group) twice daily for 6 weeks * Attend study visits at baseline and at week 7 for questionnaires and esophageal function tests * Keep a diary of their symptoms and breathing practice

Eligibility criteria

Qualifiers

Adults aged 20 to 80 years

Endoscopic finding of reflux esophagitis (LA grade A) with proton pump inhibitor (PPI) use > 2 months, or 24-hour pH monitoring showing acid exposure time (AET) > 6%, or endoscopic diagnosis of reflux esophagitis LA grade B or higher

Willingness to comply with the full training and follow-up protocol

Disqualifiers

Pregnant or breastfeeding women

History of anti-reflux surgery

Severe cardiopulmonary dysfunction or respiratory disease

Inability to perform the training exercises or attend follow-up visits

Trial design

Treatments tested in this trial

  • Volume-Oriented Incentive Spirometer
  • Diaphragmatic Breathing Exercise (DBE)
  • Usual Care and Education

Treatment groups

51 Participants
are divided into 3 treatment groups

Locations

This trial has no locations

Sponsors and collaborators