Effect of Bupivacaine Liposome Injection on Muscle Strength After Total Knee Arthroplasty

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age60-75
SponsorGeneral Hospital of Ningxia Medical University

About this trial

This study employs a randomized controlled trial to investigate whether bupivacaine liposome injection for adductor canal block can effectively improve lower limb muscle strength after total knee arthroplasty.

Eligibility criteria

Qualifiers

Patients aged 60-75 years scheduled for elective TKA;

ASA physical status classification II-III;

BMI 18-30 kg/m²;

Agreement to participate in this study and provision of signed informed consent.

Disqualifiers

Individuals with communication barriers such as language or hearing impairments;

Patients with contraindications to nerve blocks;

Severe systemic diseases, such as severe renal disease (estimated glomerular filtration rate below 50 mL/min), cardiac disease (congestive heart failure New York Heart Association Class III to IV), or severe hepatic disease defined as a current or past diagnosis of acute/subacute hepatic necrosis, acute liver failure, chronic liver disease, liver abscess, hepatic coma, or hepatorenal syndrome;

History of long-term opioid use (defined as daily or nearly daily opioid use within the past 3 months).

Trial design

Treatments tested in this trial

  • a single-injection adductor canal block
  • continuous femoral nerve block

Treatment groups

80 Participants
are divided into 2 treatment groups