This prospective, single-center observational study evaluates the effect of dapagliflozin 10 mg/day on right ventricular-pulmonary artery coupling measured by the TAPSE/PASP ratio in 72 patients with left ventricular ejection fraction \<50% after off-pump coronary artery bypass grafting (OPCAB). The primary outcome is the change in TAPSE/PASP ratio from 1 month after surgery (before dapagliflozin) to 7 months after surgery (after 6 months of dapagliflozin therapy).
Age ≥ 18 years
Elective isolated off-pump coronary artery bypass grafting (OPCAB)
Left ventricular ejection fraction (LVEF) < 50% documented on pre-operative echocardiography
Written informed consent
Concomitant valve surgery
Emergency or urgent CABG
Conversion to on-pump during surgery
Perioperative myocardial infarction (as defined by the Fourth Universal Definition of MI)