Effect of Fasting on Hypoglycemic Counterregulation in Type 1 Diabetes
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-45
SponsorUniversity of Cincinnati
About this trial
Iatrogenic hypoglycemia is still considered to be the number one barrier to effective glycemic control in patients with type 1 diabetes (T1D). In a previous study, it was observed in people without diabetes that fasting can be detrimental to the hormonal and hepatic responses to insulin-induced hypoglycemia. In the experiments described herein, the impact fasting has on hypoglycemic counterregulation in people with T1D will be determined.
Eligibility criteria
Qualifiers
males and females of any race or ethnicity
non-obese (BMI < or = to 30)
have a diagnosis of type 1 diabetes
C-peptide negative
Disqualifiers
pregnant women
cigarette smoking
Taking inflammation-targeting steroids (e.g., prednisone).
Taking medications targeting adrenergic signaling (e.g., beta-blockers, bronchodilators).
Trial design
Treatments tested in this trial
- Fasting
- Feeding
Treatment groups
10 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov