Effect of High Intensity Exercise Rehabilitation on Liver Function and Insulin Sensitivity in Patients With MASLD
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-75
SponsorUniversity Ghent
About this trial
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common liver disease worldwide, and is associated with obesity and the metabolic syndrome. Physical activity and lifestyle interventions are among the most recommended treatments for individuals with MASLD.
In this RCT, we will evaluate the effect of combined exercise training "strength and aerobic training" versus "strength and high intensity training (HIIT)". The main outcome parameter is the severity of liver steatosis. Patients will be recruited at the fatty liver clinic of the UZ Gent.
Eligibility criteria
Qualifiers
Diagnosed with MASLD by ultrasound, CAP and/or biopsy
Age between 18 and 75 years old
No significant liver fibrosis (Fibroscan < 7.5 kPa; if it is between >7.5 and <10, there must be absence of liver fibrosis in the biopsy)
Disqualifiers
Presence of other liver diseases that may contribute to the clinical presentation in the patient
Severe cardiovascular, orthopedic, physical or other illnesses that make it impossible to participate in the study's exercise rehabilitation program or where safety cannot be guaranteed
Pregnancy
Pharmacological treatment that directly affects MASLD (e.g. GLP-1 analogues)
Trial design
Treatments tested in this trial
- Combined aerobic + strength training
- Combined strength + HIIT training
Treatment groups
92 Participants
are divided into 2 treatment groupsSponsors and collaborators
University Ghent
Lead sponsor
University Hospital, Ghent
Collaborator
Source ClinicalTrials.gov