Patients with liver cirrhosis frequently exhibit dyslipidemia due to impaired hepatic lipid synthesis, altered bile acid metabolism, and portal hypertension. Laparoscopic splenectomy is commonly used to treat splenomegaly and hypersplenism in these patients, but its impact on lipid profiles over 2 years remains poorly characterized. This study will follow patients undergoing laparoscopic splenectomy to measure changes in serum lipid parameters before and after surgery, identify risk factors for lipid profile deterioration or improvement, and determine whether laparoscopic splenectomy can ameliorate dyslipidemia in the long term, thereby informing metabolic management strategies in cirrhotic patients.
Age 18-80 years, male or female
Confirmed diagnosis of liver cirrhosis (clinical, laboratory, imaging)
Splenomegaly and hypersplenism
Child-Pugh Class A or B liver function
Child-Pugh Class C liver cirrhosis
No history of portal hypertension bleeding (esophageal and gastric variceal bleeding )
Previous abdominal surgery precluding safe laparoscopic splenectomy.
Severe cardiac, pulmonary, cerebrovascular dysfunction; malignant tumors; primary hematological disorders