Effect of Modified Poco-Poco Exercise to Frailty Stages, Expression of Global DNA Methylation, GDF15 and Lamin A COP

ConditionFrail Elderly
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age60+
SponsorUniversitas Padjadjaran

About this trial

The goal of this clinical trial is to know the effect of multicomponent exercise in frail elderly in community to aging hallmarks. The main question\[s\] it aims to answer are:

1. Do global DNA methylation levels change in elderly people in Bandung after receiving modified poco-poco exercise? 2. Do GDF15 levels change in elderly people in Bandung after they are given modified poco-poco exercise? 3. Do lamin A COP levels change in elderly people in Bandung after they are given modified poco-poco exercise? 4. Does the level of frailty in elderly people in Bandung change after they are given modified poco-poco exercise?

Participants will be asked to do flexibility, balance, aerobic and strengthening exercise included in poco-poco modified exercise three times a week for 12 weeks

Eligibility criteria

Qualifiers

Frailty level is in pre-frailty

MoCA INA score above 18

Domicile in Bandung City

Willing to participate in the study after informed consent

Disqualifiers

There is a hearing impairment that may prevent the subject from receiving verbal instructions

There is uncorrected visual impairment

There are musculoskeletal disorders so that they cannot perform exercise procedures or procedures for measuring research variables

Subjects received other rehabilitation programs

Trial design

Treatments tested in this trial

  • EXERCISE TRAINING WITH OR WITHOUT MEDICATION

Treatment groups

17 Participants
are divided into 1 treatment group

Sponsors and collaborators