This study compares the effects of ibuprofen administered during surgery and within the first 24 hours after surgery, versus no ibuprofen, on cerebral oxygenation, postoperative changes in consciousness (postoperative delirium and cognitive dysfunction), length of stay in the intensive care unit, and the incidence of postoperative pain, nausea, vomiting, and pruritus in patients undergoing lung lobectomy or segmentectomy using a closed (video-assisted) method (VATS - video-assisted thoracoscopic surgery), in whom one-lung ventilation is applied.
The aim of this study is to evaluate the effects of ibuprofen on cerebral oxygenation, postoperative cognitive changes, and delirium in patients undergoing one-lung ventilation.
Patients aged 18-75 years
American Society of Anesthesiologists (ASA) Physical Status Classification System I-III
Patients scheduled for lobectomy or segmentectomy via Video-Assisted Thoracic Surgery (VATS ) with one-lung ventilation
New York Heart Association (NYHA) class I-II
Patients younger than 18 years or older than 75 years
History of alcohol or substance abuse
Patients with chronic NSAID use and/or NSAID use within the last 30 days, or NSAID allergy
Allergy to other drugs used in the study (e.g., bupivacaine)