Effect of Pre-existing Adjacent Segment Degeneration on Long-term Effectiveness After Lumbar Fusion Surgery
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorPeking University Third Hospital
About this trial
This is a prospective single-center study. Patients requiring posterior lumbar interbody fusion (PLIF) for lumbar degenerative disease are prospectively enrolled and followed. Important adjacent pre-existing degeneration factors include discs degenerated, facets and ligamentum flavum tropism which could lead to spinal canal stenosis (SCS). This study will focus on the effects of pre- existing adjacent degeneration (disc factors and spinal canal stenosis factors) on long-term postoperative outcomes.
Eligibility criteria
Qualifiers
A clear diagnosis of lumbar spinal stenosis, and surgical level of L4- S1 (The levels to be operated on were decided by matching the clinical symptomatology with the radiological findings of the spinal levels that needed decompression);
Failed at least eight weeks conservative treatment;
Disqualifiers
Unstable factors (slip, rotation, lateral bending, etc.) in adjacent segment L3/4;
Preoperative sagittal and coronal imbalance of the spine;
Lumbar infection and/or tumor diseases;
A previous history of lumbar fusion surgery.
Trial design
Treatments tested in this trial
- Pre-existing degenerative factors at adjacent segment
Treatment groups
210 Participants
are divided into 3 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov