Effect of Product Characteristics on the Abuse Liability of Nicotine Pouches
ConditionNicotine Addiction
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age21-35
SponsorEmory University
About this trial
The goal of this study is to assess the effects of nicotine concentration and its interplay with pH on sensory experience, product appeal, and abuse liability of NPs among young adults NP users.
Primary objective is to assess the effect of variation in nicotine concentration in nicotine pouches (NPs) and its interaction effect with pH level on three proximal outcomes of relevance to regulation: (1) sensory experience, (2) product appeal, and (3) abuse liability of NPs.
Eligibility criteria
Qualifiers
Current established users of nicotine pouches (have used nicotine pouches in the past 30 days & currently use nicotine pouches every day or someday)
Positive cotinine test via saliva test strip
Those who are unmotivated to quit nicotine use
Read and speak English.
Disqualifiers
Planning to cut down or quit using nicotine in the next 30 days
Currently pregnant or breastfeeding
History of stroke, seizures, high blood pressure, heart disease/problems, or cardiovascular disease contraindications for nicotine.
Trial design
Treatments tested in this trial
- Nicotine pouch: Low dose
- Nicotine pouch: High dose
- Low pH
- High pH
Treatment groups
84 Participants
are divided into 1 treatment groupSponsors and collaborators
Emory University
Lead sponsor
National Institute on Drug Abuse (NIDA)
Collaborator
Source ClinicalTrials.gov