Effect of Raised Head of the Bed on Lying Blood Pressure in Autonomic Failure

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-85
SponsorVanderbilt University Medical Center

About this trial

Many persons with autonomic failure often have high blood pressure when lying down (supine hypertension). This study is exploring the impact of decreased venous return to the heart (achieved by raising the head of the bed) to lessen supine blood pressure. If decreased venous return to the heart is effective at lowering supine blood pressure, these approaches may be utilized to treat supine hypertension non-pharmacologically. Raising the head of the bed decreases the amount of blood returning to the heart due to the effects of gravity. In this case, the decreased blood return to the heart may decrease blood pressure.

Eligibility criteria

Qualifiers

Patients with autonomic failure and with supine hypertension from all races

Males and females, between 18 to 85 years

Disqualifiers

All medical students

Pregnant women

High-risk patients (for example: heart failure, symptomatic coronary artery disease, liver impairment, history of stroke or myocardial infarction)

History of serious allergies or asthma.

Trial design

Treatments tested in this trial

  • Tilt
  • Elevated trunk
  • Tilt - In home
  • Elevated Trunk - In home

Treatment groups

44 Participants
are divided into 4 treatment groups