Airway resistance will be measured using the forced oscillation technique (FOT). The parameters Rrs, Xrs, and ∆Xrs will be compared before and after a pulmonary rehabilitation cycle at moderate altitude. Additionally, the differences between low and moderate altitude will also be examined.
Aged ≥18 years
Stable clinical condition for >3 weeks (e.g., no exacerbations)
Resting SpO₂ ≥88% and exercise-induced hypoxemia defined as a drop in SpO₂ of ≥4% and/or a level below 90% during the 6MWT
Informed consent documented by signature
Severe daytime resting hypoxemia (SpO₂ <88%)
Long-term oxygen therapy
Unstable clinical condition requiring adjustment of pharmacological or other treatment modalities, need for intensive care, or presence of relevant severe comorbidities
Inability to comply with study procedures (e.g., due to language barriers, psychological disorders, neurological or orthopedic impairments, walking disability, or inability to ride a bicycle)
Eastern Switzerland University of Applied Sciences
Lead sponsor
National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov
Collaborator
University of Zurich
Collaborator