In this parallel, multicenter, single-blind randomized controlled trial, mechanical ventilated patients will be randomly assigned to two groups. One receives remimazolam to achieve sedation goals, while the other receives Midazolam. The primary outcome is the effect of remimazolam on duration of mechanical ventilated of critical patients compared to midazolam.
Critical ill patients that are mechanically ventilated within the first 48h of admission to the ICU and who would remain in the ICU for over 72h were enrolled in this study.
Age 18-80 years.
Voluntary informed consent.
Surgical treatment is performed within 24 hours.
Craniocerebral injury, post neurosurgery, non drug coma, mental illness or peripheral neuropathy.
Heart rates are less than 50 beats / min or severe atrioventricular block without pacemaker support.
The mean arterial pressure is less than 55 mmHg even though fluids and vasoactive drugs are administrated.
Zhujiang Hospital
Lead sponsor
Integrated traditional Chinese and Western Medicine Hospital of Southern Medical University
Collaborator
First Affiliated Hospital of Shantou University Medical College
Collaborator
Affiliated Hospital of Guangdong Medical University
Collaborator
Yunfu People's Hospital
Collaborator
Zhongshan Hospital Of Traditional Chinese Medicine
Collaborator
Guangdong Province Traditional Medical hospital
Collaborator
The Third Affiliated Hospital of Guangzhou Medical University
Collaborator