Effect of Remote Ischemic Preconditioning on Early Neurological Deterioration in Acute Perforating Artery Infarction
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorJinling Hospital, China
About this trial
This study aims to conduct a prospective, randomized, double-blind, multicenter, parallel-controlled, group-sequential trialto scientifically evaluate the safety and efficacy of remote ischemic preconditioning (RIC) in preventing early neurological deterioration (END) in patients with acute perforating artery infarction (PAI).
Eligibility criteria
Qualifiers
Age 18 years or older;
Diagnosed with acute ischemic stroke;
Clinical symptoms consistent with perforating artery infarction (NIHSS score ≤5, with consciousness item 1a ≤1);
Time from onset to randomization within 48 hours;
Disqualifiers
Received intravenous thrombolysis or endovascular treatment prior to randomization;
Secondary stroke caused by brain tumor, traumatic brain injury, hematologic disorders, or other conditions;
History of intracranial hemorrhage;
Presence of RIC contraindications, such as severe upper limb soft tissue injury, fracture, subclavian artery stenosis, or peripheral vascular disease;
Trial design
Treatments tested in this trial
- remote ischemic preconditioning
- sham remote ischemic preconditioning
Treatment groups
910 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov