The goal of this pilot clinical trial is to learn if a subtle energy transmission and Tao Calligraphy Mindfulness Practice works to improve mitochondrial DNA. The main questions it aims to answer are:
* Does Tao Calligraphy Mindfulness practice improve mitochondrial DNA content in peripheral blood leucocytes in adults? * Will this improvement of mitochondrial DNA content in peripheral blood leucocytes be statistically significant? Researchers will compare the values of mitochondrial DNA content in peripheral blood leucocytes at beginning of the mindfulness practices to the values at 3 months, 6 months and 12 months of practice group.
Participants will:
* have blood samples will drawn at accredited institutions and analyzed for Mitochondrial DNA content in Leucocytes upon entry into the study - Baseline time point; at 3-months time point, at six-months time point and at twelve-months time point. * All participants will complete the set of 3 questionnaires upon entry into the study - Baseline time point; at 3-months time point, at six-months time point and at twelve-months time point. * Practice the Mindfulness with Tao Calligraphy minimum 30 minutes daily.
Age 19 and over
Willingness and ability to comply with data collection requirements
Submission of required documentation before entering the study, including informed consent and consent to release of information
Healthy or Ill, with the exception of genetic illnesses and cancer (for which treatments could negatively impact measurement) and serious mental disorders (e.g. bipolar disorder, schizophrenia, psychosis),
Not meeting any of the inclusion criteria
Bipolar disorders, other serious mental disorders (e.g. schizophrenia, psychosis), genetic illnesses (primarily affected chromosomes), and cancer (treatment could negatively impact telomere during research period)
inability to sign consent and follow instructions
Unwillingness to participate in data gathering
Single group
Mindfulness practice with Tao Art (Calligraphy and Song Greatest Love)
Other interventionDuring mindfulness practice with Tao Art (Calligraphy and Greatest Love Song), participants will repeatedly trace the lines of calligraphy with fingers while listening to, singing, or chanting with Tao Song. This enables them to achieve deep concentration, while maintaining fully alert state. The practice can be done in sitting or standing, depending on the health status and age and will last 30 minutes and is done daily for 12 months.
Mean Change from Baseline in Mitochondrial-to-nuclear genome ratio (Mitochondrial DNA content) in peripheral blood Leukocytes at 3 months, 6 months and 12 months
Genomic DNA is extracted from peripheral blood and DNA concentration and purity are assessed by spectrophotometer. Mitochondrial DNA content in leukocytes is quantified by real-time quantitative PCR. Calculating Mitochondrial DNA content is done as follows: Ct values for Mitochondrial DNA targets are normalized to the nuclear gene Ct using the delta-delta cycle threshold method, using equation: Mitochondrial DNA content = relative Mitochondrial DNA abundance / nuclear DNA abundance. This ratio reflects the relative number of mitochondrial genomes per nuclear genome in leukocytes. The normal range for the mitochondrial-to-nuclear genome ratio (Mitochondrial DNA/ Nuclear DNA) in human blood leukocytes is approximately 1.2 to 1.8.
Mean Change from Baseline in Quality of Life Scores on 36-item short-form Quality of Life Questionnaire (SF-36) at 3 months, 6 months and 12 months
A 36-item short-form Quality of Life Questionnaire (SF-36) was constructed to survey health status. The investigators chose the longer 36-item version to assess the impact of the Tao art mindfulness practice and drinking energized water on Quality of Life of participants with unipolar depression. The SF-36 includes one multi-item scale for eight health concepts: 1. limitations in physical activities; 2. limitations in social activities; 3. limitations in usual role activities; 4. bodily pain; 5. general mental health (psychological distress and well-being); 6. limitations in usual role activities because of emotional problems; 7. vitality (energy and fatigue); 8. general health perceptions. Through a complex calculation, eight scores are derived from answers to 36 questions of SF-36. Finally, these eight scores are linearly transformed to a 0-to-100 scale, with 100 being the best possible outcome.
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