About this trial
This study will examine the effects of varying liquid viscosity on swallow physiology in infants with oropharyngeal dysphagia and brief resolved unexplained event (BRUE) and other children with dysphagia that would be at risk for symptoms of swallow dysfunction.
Eligibility criteria
Qualifiers
Age 0 to 21 years
Admitted to Boston Children's Hospital after experiencing first lifetime BRUE, or with dysphagia symptoms such that they would be at risk for BRUE or other symptoms of swallowing difficulty
Have had videofluoroscopic swallow study performed or might have future videofluoroscopic swallow study performed.
Disqualifiers
Any pre-existing medical diagnoses that exclude brief resolved unexplained event diagnosis including seizure disorders and cyanotic congenital heart disease
Any nasal/pharyngeal/esophageal anomalies that might affect safe placement of the pharyngeal motility catheter
Children fed exclusively by enteral tube
Allergy to rice cereal or Gelmix thickener, which will be used to adjust liquid viscosity
Trial design
Treatments tested in this trial
- Thin liquid swallows
- Slightly thickened liquid swallows
- Mildly thickened liquid swallows
- Moderately thickened liquid swallows
Treatment groups
Sponsors and collaborators
Boston Children's Hospital
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator