Effect of Thickened Feeds on Swallow Physiology in Children With Dysphagia

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
AgeUp to 21
SponsorBoston Children's Hospital

About this trial

This study will examine the effects of varying liquid viscosity on swallow physiology in infants with oropharyngeal dysphagia and brief resolved unexplained event (BRUE) and other children with dysphagia that would be at risk for symptoms of swallow dysfunction.

Eligibility criteria

Qualifiers

Age 0 to 21 years

Admitted to Boston Children's Hospital after experiencing first lifetime BRUE, or with dysphagia symptoms such that they would be at risk for BRUE or other symptoms of swallowing difficulty

Have had videofluoroscopic swallow study performed or might have future videofluoroscopic swallow study performed.

Disqualifiers

Any pre-existing medical diagnoses that exclude brief resolved unexplained event diagnosis including seizure disorders and cyanotic congenital heart disease

Any nasal/pharyngeal/esophageal anomalies that might affect safe placement of the pharyngeal motility catheter

Children fed exclusively by enteral tube

Allergy to rice cereal or Gelmix thickener, which will be used to adjust liquid viscosity

Trial design

Treatments tested in this trial

  • Thin liquid swallows
  • Slightly thickened liquid swallows
  • Mildly thickened liquid swallows
  • Moderately thickened liquid swallows

Treatment groups

200 Participants
are divided into 4 treatment groups

Sponsors and collaborators

Boston Children's Hospital

Lead sponsor

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Collaborator