Effect of tNGS on CAP Patients With Initial Treatment Failure
ConditionCommunity Acquired Pneumonia (CAP)
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorCapital Medical University
About this trial
This is a multicenter, randomized controlled trial designed to evaluate the impact of tNGS in patients with community-acquired pneumonia who experience initial treatment failure.
Eligibility criteria
Qualifiers
Adults (age ≥ 18 years)
Diagnosed of community-acquired pneumonia
Initial treatment failure
Disqualifiers
tNGS or mNGS already performed on respiratory samples during the current illness
Suspected lung abscess or empyema
Cerebral infarction within the past three months
Dysphagia
Trial design
Treatments tested in this trial
- Targeted next-generation sequencing
- Conventional microbiological testing
- Follow-up at Day 30
Treatment groups
524 Participants
are divided into 2 treatment groupsSponsors and collaborators
Capital Medical University
Lead sponsor
China-Japan Friendship Hospital
Sponsor institution
China-Japan Friendship Hospital
Collaborator
Beijing Municipal Health Commission
Collaborator
Source ClinicalTrials.gov