Effect of Vitamin A Supplementation on Idiopathic Scoliosis
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age6-15
SponsorSecond Affiliated Hospital of Wenzhou Medical University
About this trial
This study aims to investigate whether vitamin A supplementation can influence spinal curve magnitude in idiopathic scoliosis children and potentially prevent its de novo development.
Eligibility criteria
Qualifiers
Age between 6 and 15 years.
Biochemically confirmed vitamin A deficiency (serum retinol < 0.20 mg/L) or insufficiency (serum retinol 0.20-0.29 mg/L).
Has undergone radiographic evaluation (standing full-spine X-ray) for idiopathic scoliosis at the initial clinic visit.
Skeletally immature (Risser sign 0-3) with a major Cobb angle < 40 degrees at baseline.
Disqualifiers
Unwillingness or inability to comply with all study procedures and follow-up visits.
Plans to relocate outside the study area within the next 24 months.
Previous high-dose vitamin A supplementation therapy within the past 12 months.
Clinical signs of severe vitamin A deficiency syndrome (e.g., xerophthalmia, Bitot's spots).
Trial design
Treatments tested in this trial
- Vitamin A
- Nutritional Education
Treatment groups
140 Participants
are divided into 2 treatment groupsSponsors and collaborators
Second Affiliated Hospital of Wenzhou Medical University
Lead sponsor
The Children's Hospital of Zhejiang University School of Medicine
Collaborator
Ningbo No. 1 Hospital
Collaborator
Ningbo No.2 Hospital
Collaborator
The Third Affiliated Hospital of Wenzhou Medical University
Collaborator
Source ClinicalTrials.gov