This randomized, double-blind, split-mouth clinical trial evaluates the effectiveness of at-home dental bleaching using customized nightguards fabricated by digital (3D-printed CAD-CAM) and conventional methods, with and without reservoirs. Adult participants with good general and oral health and a baseline tooth shade of A2 or darker undergo bleaching with 10% carbamide peroxide. Outcomes include tooth color change (subjective and spectrophotometric measures), tooth sensitivity, gingival irritation, patient comfort, and patient satisfaction over time.
Adults aged 18 years or older
Good general and oral health
No current medical treatment (self-reported)
No need for surgical, endodontic, periodontal, or restorative dental treatment
Previous tooth bleaching treatment
Orthodontic appliances or prostheses that interfere with treatment
Severe intrinsic discoloration (e.g., tetracycline staining, fluorosis, or endodontically treated teeth with discoloration)
Pregnancy or lactation