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Effectiveness of Low -Versus High -Volume High -Intensity Interval Training in Patients With Chronic Heart Failure

ConditionChronic Heart Failure
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorCairo University

About this trial

this study aims to investigate the effect of low vs high volume- high intensity interval training on functional capacity and quality of life in chronic heart failure patients

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Chronic stable heart failure patient with reduced ejection fraction (EF <40)

Age Above 18 years old

Both males and females

The ability to provide informed consent

Disqualifiers

Based on the Scientific Statement from the American Heart Association: contraindications for exercise Testing and Training. (Fletcher et al., 2013)

Acute myocardial infarction (MI), within 2 days

Ongoing unstable angina

Uncontrolled cardiac tachy or brady arrhythmia with hemodynamic compromise

Trial design

Design model

Parallel

Treatments tested in this trial

  • low-volume high intensity interval training

    Other intervention

    Low-volume HIIT (LV-HIIT) is a particularly time-efficient subtype of interval training, which has gained increasing attention in recent years. As per the previous definition, these brief training protocols typically involve≤10 min of intense exercise within a session lasting≤30 min including warm-up, recovery phases between intervals, and cool-down

  • High volume high intensity interval training

    Other intervention

    long (2-4 min) bouts of high (not maximum) intensity exercise interspersed with recovery periods which have wide varieties in the protocols according to the intensity, duration, and number of intervals performed

  • Standard medical treatment

    Drug

    standard medical treatment for chronic heart failure as per international guidlines

Treatment groups

45 Participants
are divided into 3 treatment groups
Group A: Low volume high intensity interval trainingExperimental treatment 2 interventions
Group B: high volume high intensity interval trainingExperimental treatment 2 interventions
Group C: control groupOther 1 intervention

Trial outcomes

Primary outcomes

1

6 minute walk test

self-paced submaximal field exercise test to assess submaximal functional capacity of the patient , the distance walked by the patient for six minutes will be measured by meters

Time frame
at enrolment and at the end of treatment at 8 weeks
2

2D Echocardiographic parameters

Left ventricle geometry: left ventricular end-diastolic diameter (LVEDD) mm, left ventricular end-systolic diameter (LVESD) mm, left ventricular end-systolic volume (LVESV) ml. and, left ventricular end-diastolic volume (LVEDV) ml. Left ventricle Systolic function: left ventricular ejection fraction (LVEF) % Left ventricle Diastolic function :E wave cm/s: early diastolic mitral inflow velocity, A wave cm/s: diastolic mitral inflow velocity during late atrial contraction , E/A ratio

Time frame
at enrollment and at the end of treatment at 8 weeks

Secondary outcomes

1

Minnesota living with heart failure questionnaire (MLHFQ)

The Minnesota Living with Heart Failure Questionnaire (MLHFQ) is the tool most widely used and recognized to assess HRQOL in adults with Hf, was developed in 1987 by Thomas Rector, focusing on the underlying relationship between pathophysiology, symptoms, functional limitations, and psychological distress, it measures the impacts of symptoms and treatment on different dimensions of HRQOL in HF patients.

Time frame
at enrollment and at the end of treatment at 8 weeks

Other outcomes

Locations

1

Map coordinates are unavailable for these locations. Locations are shown below instead.

Cairo UniversityRecruiting Cairo, Giza GovernorateEgyptEgypt

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Cairo University

Lead sponsor

Source ClinicalTrials.gov
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