This study seeks to explore changes in the neural pathways and arm function following a breathing intervention in the multiple sclerosis (MS) population. The breathing intervention, known as Acute Intermittent Hypoxia (AIH), involves breathing brief bouts of low levels of oxygen. Research has found AIH to be a safe and effective intervention resulting in increased ankle strength in people with MS. Here, the study examines arm and hand function before and after AIH. In order to better understand the brain and spinal cord response to AIH, the investigators will measure muscle response, and signals sent from the brain to the arm muscles before and after AIH.
Diagnosis of relapsing-remitting MS according to the McDonald criteria, over 5 years ago
Relapse free for at least 6 months
Expanded Disability Status Scale (EDSS) ≤7
Index finger abduction strength <5 according to Medical Research Council Scale, or 9-Hole Peg Test score >20 seconds in at least one hand
Another diagnosis (e.g., peripheral neuropathies or orthopedic) affecting upper limb function
Mini-Mental State Examination (MMSE) score <24
Modified Ashworth Scale score >3 on elbow joint
Uncontrolled hypertension or hypotension (outside 140/90 and 85/55 mmHg)
Shirley Ryan AbilityLab
Lead sponsor
National Multiple Sclerosis Society
Collaborator