Effects of Acute Sleep Deprivation on Individuals With Different APOE Genotypes
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-40
SponsorYuhui Qiu
About this trial
This study aims to investigate the effects of 24-hour acute sleep deprivation on plasma Alzheimer's disease biomarkers and multi-omics in individuals with different APOE genotypes, to elucidate the potential role of acute sleep deprivation in AD risk.
Eligibility criteria
Qualifiers
Age 18-40 years, gender not limited
Healthy (with no clinically significant abnormal findings in the physical examination report or self-reporting as healthy) and not on medications
Cognitively normal (Mini-Mental State Examination (MMSE) score > 28)
Sleep duration of 7-9 hours per night, good sleep quality (Pittsburgh Sleep Quality Index (PSQI) ≤ 5 points)
Disqualifiers
Presence of day-night sleep reversal
Shift work within the past 6 months
Travel across time zones or experience of jet lag within the past three weeks
Current smoking or nicotine use; alcohol consumption exceeding five standard units per week (one standard alcohol unit is defined as 10 mL [or 8 g] of pure alcohol)
Trial design
Treatments tested in this trial
- Sleep Deprivation
Treatment groups
60 Participants
are divided into 2 treatment groupsSponsors and collaborators
Yuhui Qiu
Lead sponsor
Guangdong Provincial Hospital of Traditional Chinese Medicine
Sponsor institution
Source ClinicalTrials.gov