Effects of Adenoidectomy on Symptoms and IgE Levels in Children With AR
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age3-12
SponsorTongji Hospital
About this trial
This study aims to evaluate the effects of conservative management versus surgical intervention (adenoidectomy alone or adenotonsillectomy) on symptoms and local IgE levels in children with allergic rhinitis (AR) accompanied with adenotonsillar hypertrophy. The primary objectives include the impact of conservative management and surgical interventions on AR symptoms and local IgE levels. The second outcomes include serum IgE levels, inflammatory cell profiles within the nasal mucosa, and postoperative complications.
Eligibility criteria
Qualifiers
Children with physician-diagnosed allergic rhinitis and typical symptoms (nasal obstruction, watery rhinorrhea, paroxysmal sneezing);
Co-existing adenoidal and tonsillar hypertrophy meeting surgical indications;
No systemic or topical corticosteroids, leukotriene antagonists, or antihistamines within the past 3 months.
Disqualifiers
Prior adenoidectomy, tonsillectomy, or radio-frequency ablation;
Nasal polyps, cystic fibrosis, primary ciliary dyskinesia, fungal rhinosinusitis, systemic vasculitis/granulomatosis, tumor, or immunodeficiency;
Endoscopic nasal surgery within 6 months or severe asthma precluding surgery;
Upper respiratory infection within 4 weeks;
Trial design
Treatments tested in this trial
- Drug therapy (NASONEX nasal spray)
- Adenoidectomy
- Adenotonsillectomy
Treatment groups
36 Participants
are divided into 3 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov