Health TrialsbyHealthPanel

Effects of E-Cigarette Flavors on Adult E-Cigarette Users With Opioid Use Disorder

ConditionsNicotine Use DisoderOpioid Use Disorder
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age21+
SponsorPrisma Health-Upstate

About this trial

This study examines the effects of e-cigarette (EC) flavors among adults with opioid use disorder (OUD) receiving buprenorphine treatment who currently use e-cigarettes. Participants will smell and rate 11 EC flavors based on appeal, sensory characteristics, and likelihood of future use. Researchers will examine how different flavor profiles influence the appeal and reinforcing effects of ECs in this population. The goal is to identify EC flavors that may enhance the acceptability of ECs as a potential harm-reduction strategy among adults with OUD receiving buprenorphine treatment.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Adults aged 21 years or older.

Current e-cigarette users who report e-cigarette use on ≥20 of the past 30 days.

Former daily cigarette smokers who currently smoke on ≤19 days per month and no more than 5 cigarettes per day.

Diagnosed with opioid use disorder (OUD).

Disqualifiers

None

Trial population

E-cigarette users with opioid use disorder receiving burpenorphine

Trial design

Design model

Other

Time perspective

Prospective

Treatments tested in this trial

  • Sweet-cooling

    Drug

    Sweet-cooling EC flavor

  • Sweet non-cooling EC flavor

    Drug

    Sweet non-cooling flavor

  • Tobacco flavor EC

    Drug

    Tobacco flavor EC

Treatment groups

No treatment groups listed

Trial outcomes

Primary outcomes

1

Perceived Sweetness

Perceived sweetness of each e-cigarette flavor will be assessed using a one-item VAS ranging from "Not sweet at all" to "Extremely sweet," with higher scores indicating greater perceived sweetness.

Time frame
Baseline session
2

Perceived Coolness/Freshness

Perceived coolness/freshness of each e-cigarette flavor will be assessed using a one-item VAS ranging from "Not cool/fresh at all" to "Extremely cool/fresh," with higher scores indicating greater perceived coolness/freshness.

Time frame
Baseline session
3

Perceived Flavor Strength

Perceived flavor strength will be assessed using a one-item VAS ranging from "Very weak" to "Very strong," with higher scores indicating greater perceived flavor strength.

Time frame
Baseline session
4

Perceived Harshness/Irritation

Perceived harshness/irritation of each e-cigarette flavor will be assessed using a one-item VAS ranging from "Not harsh/irritating at all" to "Extremely harsh/irritating," with higher scores indicating greater perceived harshness/irritation.

Time frame
Baseline session

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Prisma Health-Upstate

Lead sponsor

National Institute on Drug Abuse (NIDA)

Collaborator

Source ClinicalTrials.gov
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