About this trial
Premature babies often need help breathing for a longer period of time. Traditionally, this is done with a breathing aid called NCPAP (nasal continuous positive airway pressure). This treatment is safe and effective, but it is very time-consuming and can sometimes have side effects. In the present research project, the investigators want to find out whether another type of breathing aid called NHF (nasal high flow therapy) is just as effective for stable premature babies. The investigators suspect that NHF is just as effective, but easier to use and more comfortable.
Eligibility criteria
Qualifiers
Preterm infants up to 31+6 weeks GA admitted to the Division of Neonatology at Inselspital Bern, Switzerland or Division of Neonatology at the University Medical Center of the Johannes Gutenberg-University Mainz, Germany (inborn or outborn)
>2nd day of life (defined as date day)
≤ 2 apneas with concomitant bradycardias (<100/min) per hour for the previous 6 hours
FiO2 ≤ 0.3 and not increasing
Disqualifiers
Significant fetal anomalies
Primary palliative care
Stable on NCPAP 6 cm H2O according to stability criteria for more than 120 hours
Trial design
Treatments tested in this trial
- NHF high
- NHF low
- NCPAP