This randomized clinical trial aims to evaluate the effects of high-frequency chest wall oscillation (HFCWO) combined with concurrent training on cough, sputum clearance, exercise tolerance, and respiratory muscle strength in patients with Cystic Fibrosis. A total of 24 participants meeting inclusion criteria will be randomly allocated into two groups: Group A will receive HFCWO plus concurrent training, while Group B will receive HFCWO alone for 8 weeks. Outcomes will be measured before and after intervention using the 6-minute walk test, spirometry, Leicester Cough Questionnaire, sputum volume, and the Cystic Fibrosis Questionnaire-Revised. The study will be conducted at Pulmonary Rehabilitation Unit, Gulab Devi Hospital and Mayo Hospital, Lahore. Statistical analysis will be performed using IBM SPSS Statistics, with significance set at p \< 0.05.
Diagnosed with Cystic Fibrosis, confirmed by genotype or sweat chloride >60 mmol/L.
Age 16-35 years.
Both male and female participants.
Stable clinical condition (no exacerbations in the last 2 weeks).
Active hemoptysis or pneumothorax.
Risk of hemodynamic instability or severe hypoxia.
Acute airway infection.
Cognitive disorders affecting compliance.