Effects of Increasing Mean Arterial Pressure on Renal Function in Patients With Shock and With Elevated Central Venous Pressure

ConditionShock
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity Hospital, Angers

About this trial

The purpose of this study is to assess the effect of a higher mean arterial pressure on renal function for patients with shock and elevated central venous pressure.

Eligibility criteria

Qualifiers

Adult patients (≥ 18 years old )

Arterial hypotension requiring the etablishment of catecholamines

Norepinephrine dose ⩾ 0.1µg/kg/min at the inclusion

High central venous pressure ≥ 12mmHg

Disqualifiers

Anuria

Patient with an emergency indication of renal replacement therapy (severe hyperkalemia, severe metabolical acidosis with pH <7.15, acute pulmonary edema due to fluid overload resulting in severe hypoxemia, serum urea concentration > 40 mmol/l)

Pregnant, lactating or parturient woman

Patient deprived of liberty by judicial or administrative decision

Trial design

Treatments tested in this trial

  • increase of mean arterial pressure at 65-70 mmHg
  • increase of mean arterial pressure at 80-85 mmHg

Treatment groups

30 Participants
are divided into 2 treatment groups

Sponsors and collaborators