Effects of Individualized PEEP Guided by Driving Pressure on Postoperative Atelectasis in Patients With Morbid Obesity
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-60
SponsorYongtao Sun
About this trial
Atelectasis is a common complication in patients undergoing surgery under general anesthesia, particularly in obese patients. Postoperative atelectasis could last for more than 24h and contribute to a variety of other complications, including hypoxemia and pneumonia. We plan to conduct a single-center, randomized controlled trial in patients undergoing bariatric surgery to test the hypothesis that driving pressure guided PEEP could reduce the postoperative atelectasis.
Eligibility criteria
Qualifiers
Age 18 to 60 years old;
Body mass index (BMI) ≥ 40 kg/m2;
ASA classification I to III;
Signing the informed consent form for this clinical study;
Disqualifiers
Respiratory infection within 4 weeks; severe respiratory system diseases; history of pulmonary and/or thoracic surgery; neuromuscular dysfunction;
Serious cardiac, renal or haematopoietic diseases;
Contraindications to PEEP；
Trial design
Treatments tested in this trial
- Individualized PEEP group
- Fixed PEEP group
Treatment groups
52 Participants
are divided into 2 treatment groupsSponsors and collaborators
Yongtao Sun
Lead sponsor
Qianfoshan Hospital
Sponsor institution
Source ClinicalTrials.gov